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Über Pterinchemie 80. Mitteilung Die Herstellung von (6 RS )Tetra‐ und (6 RS )Pentaacetyl‐5,6,7,8‐tetrahydro‐L‐bioplerinen
Author(s) -
Ganguly Subhendu Narayaa,
Viscontini Max
Publication year - 1982
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19820650341
Subject(s) - chemistry , tetra , acetic anhydride , diastereomer , medicinal chemistry , boiling , stereochemistry , organic chemistry , catalysis
Preparation of (6 RS )Tetra‐ and (6 RS )‐Pentaacetyl‐5,6,7,8‐tetrahydro‐L‐biopterines Boiling of (6 RS ) l′‐ O ,2′‐ O ,2‐N‐triacetyl‐5,6,7,8‐tetrahydro‐L‐biopterine in acetic anhydride as described in [2], leads to a mixture of the diastereoisomeric (6 R )‐ and (65)‐l′‐ O ,2′‐ O ,2‐ N ‐,5,8‐pentaacetyl‐5,6,7,8‐L,‐biopterines. One of the diastereoisomers can be obtained as pure crystals. It corresponds to the pentaacetate of the natural (6 R )‐ or (6 S ).,5,6,7,8‐tetrahydro‐L‐biopterine. For the preparation of the earlier described (6 RS )‐ and (6 S )‐tetraacetyl‐tetrahydro‐L‐biopterines [2] improved conditions are reported.