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Synthesis, Conformation, and Interactions with Small Molecules of Bis (Cyclic Dipeptides)
Author(s) -
Tomiyasu Hiroshi,
Kinjura Shunsaku,
Imanishi Yukio
Publication year - 1982
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19820650315
Subject(s) - chemistry , dipeptide , intramolecular force , cyclic peptide , circular dichroism , molecule , stereochemistry , aqueous solution , nuclear magnetic resonance spectroscopy , crystallography , raman spectroscopy , peptide , organic chemistry , biochemistry , physics , optics
Bis (cyclic dipeptides), cyclo and S , S ′‐bis(cyclo(hemiCys‐Pro)), were synthesized. These bis (cyclic dipeptides) very efficiently formed complexes with Ba 2+ and Na + owing to intramolecular cooperation of two cyclicdipeptide moieties, the bis‐effect. Cyclo stacked sodium 8‐anilino‐1‐naphthalensulfonate in aqueous solution. These properties of complexation were controlled by the nature of the bridge connecting two cyclic dipeptide moieties. The geometry of the complex between S , S ′‐bis (cyclo (hemiCys‐Pro)) and metal ion was investigated with the help of circular dichroism, nuclear magnetic resonance, and Raman spectroscopy.