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Synthese makrocyclischer Lactone durch Ringerweiterung. Vorläufige Mitteilung
Author(s) -
Kostova Kalina,
LorenziRiatsch Annalaura,
Nakashita Yoshihiko,
Hesse Manfred
Publication year - 1982
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19820650124
Subject(s) - chemistry , lactone , nitro , ring (chemistry) , medicinal chemistry , stereochemistry , organic chemistry , alkyl
Synthesis of Macrocyclic Lactones by Ring Enlargement Reaction Treatment of 3‐(1‐nitro‐2‐oxocyclohexyl)propanal ( 1 ) prepared by Michael addition of 2‐nitrocyclohexanon and acrylaldehyde with methyltri (2‐propoxy)tita‐nium yielded a mixture of 2 and 3 which was converted into 6‐nitro‐9‐decanolide ( 4 ).
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