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Synthesis and Absolute Configuration of New Trichloro Steroids with Cyclopropane‐Containing Side Chains
Author(s) -
Lang Robert W.,
Djerassi Carl,
Strong Phyllis D.,
Swenson Dale C.,
Duax William L.
Publication year - 1981
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19810640847
Subject(s) - chemistry , absolute configuration , cyclopropane , absolute (philosophy) , side chain , stereochemistry , crystal structure , organic chemistry , ring (chemistry) , philosophy , epistemology , polymer
Abstract The determination of the absolute configuration of the trichloro steroids 2a and 2c (cf. Scheme 1) by means of two X‐ray crystal structure analyses is reported and applies also to the determination of the absolute configurations of several derived steroidal cyclopropanes [1]. The preparation of the chlorinated derivatives 2a‐c is described and the spectroscopic properties of 1 and 2 are summarized.