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Low Temperature Grignard Reactions with Pure Mg Slurries. Trapping of cyclopropylmethyl and benzocyclobutenylmethyl Grignard reagents with CO 2
Author(s) -
Künding Ernst Peter,
Perret Celia
Publication year - 1981
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19810640817
Subject(s) - chemistry , grignard reagent , grignard reaction , carbonation , acetic acid , benzaldehyde , yield (engineering) , reagent , bromide , slurry , medicinal chemistry , organic chemistry , nuclear chemistry , catalysis , metallurgy , materials science , composite material
Cyclopropylmethyl bromide reacts readily at −75° with a Mg/THF slurry formed by evaporation of Mg in a rotating‐solution reactor to yield after carbonation cyclopropyl acetic acid and 4‐pentenoic acid in a ratio of 11:1. Addition of benzaldehyde to the Grignard solution again predominantly yields the addition product containing the cyclopropylmethyl unit. Using the same low temperature Grignard method, benzocyclobutenyl acetic acid is isolated upon carbonation of the Grignard reagent derived from the corresponding bromide, whereas under normal conditions o ‐vinylphenylacetic acid, the product corresponding to ring cleaved Grignard is obtained.