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Synthetic Methods and Reactions. Part 106. Suppression of anchimerically assisted rearrangement products in the synthesis of α‐fluorocarboxylic acids from α‐amino acids with 48:52 (w/w) hydrogen fluoride/pyridine [1]
Author(s) -
Olah George A.,
Surya Prakash G. K.,
Chao Yah Li
Publication year - 1981
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19810640806
Subject(s) - chemistry , hydrogen fluoride , pyridine , reagent , fluoride , hydrogen , medicinal chemistry , amino acid , organic chemistry , inorganic chemistry , biochemistry
Anchimerically assisted rearrangement, observed in the fluorination of some α‐amino acids with 70 : 30 (w/w) hydrogen fluoride/pyridine (by weight) in the presence of NaNO 2 , is substantially or fully suppressed by using the less acidic reagent 48 : 52 (w/w) hydrogen fluoride/pyridine.