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Nucleosides and Nucleotides. Part 18. p ‐nitrobenzenesulfonyl nitroimidazole as a new condensing agent in the triester synthesis of oligonucleotides
Author(s) -
Leach Colin A.,
Waldmeier Felix,
Tamm Christoph
Publication year - 1981
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19810640804
Subject(s) - chemistry , nucleotide , nitroimidazole , oligonucleotide , stereochemistry , combinatorial chemistry , nucleic acid , nucleoside , organic chemistry , biochemistry , dna , gene
p ‐Nitrobenzenesulfonyl nitroimidazole ( p ‐NBSNI) ( 5 ) has been shown to be an efficient and convenient condensing agent in the coupling of protected nucleotide fragments. Its utility has been demonstrated by a direct comparison with previously‐described condensing agents in the synthesis of various di‐ and tetradeoxy‐nucleotides.