(25  S )‐1α, 25, 26‐Trihydroxycholecalciferol, a New Vitamin D 3  Metabolite: Synthesis and Absolute Stereochemistry at C(25) | Zendy

Partridge John J. | Zendy; Shiuey ShianJan | Zendy; Chadha Naresh K. | Zendy; Baggiolini Enrico G. | Zendy; Hennessy Bernard M. | Zendy; Uskoković Milan R. | Zendy; Napoli Joseph L. | Zendy; Reinhardt Timothy A. | Zendy; Horst Ron L. | Zendy

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(25 S )‐1α, 25, 26‐Trihydroxycholecalciferol, a New Vitamin D 3 Metabolite: Synthesis and Absolute Stereochemistry at C(25)

Author(s) -

Partridge John J.,

Shiuey ShianJan,

Chadha Naresh K.,

Baggiolini Enrico G.,

Hennessy Bernard M.,

Uskoković Milan R.,

Napoli Joseph L.,

Reinhardt Timothy A.,

Horst Ron L.

Publication year - 1981

Publication title -

helvetica chimica acta

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.74

H-Index - 82

eISSN - 1522-2675

pISSN - 0018-019X

DOI - 10.1002/hlca.19810640718

Subject(s) - chemistry , metabolite , derivative (finance) , stereochemistry , absolute configuration , vitamin , high performance liquid chromatography , chromatography , biochemistry , financial economics , economics

The 1α, 25, 26‐trihydroxy metabolite of vitamin D 3 , isolated from bovine serum, was shown to possess the (25 S )‐configuration by HPLC. comparison of the 1, 3, 26‐triacetate derivative with authentic (25 R )‐ and (25 S )‐samples. The convergent synthesis of (25 R )‐1α, 25, 26‐ and (25 S )‐1α, 25, 26‐trihydroxycholecalciferols ( 10a ) and ( 10b ) has been accomplished.

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