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(25 S )‐1α, 25, 26‐Trihydroxycholecalciferol, a New Vitamin D 3 Metabolite: Synthesis and Absolute Stereochemistry at C(25)
Author(s) -
Partridge John J.,
Shiuey ShianJan,
Chadha Naresh K.,
Baggiolini Enrico G.,
Hennessy Bernard M.,
Uskoković Milan R.,
Napoli Joseph L.,
Reinhardt Timothy A.,
Horst Ron L.
Publication year - 1981
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19810640718
Subject(s) - chemistry , metabolite , derivative (finance) , stereochemistry , absolute configuration , vitamin , high performance liquid chromatography , chromatography , biochemistry , financial economics , economics
Abstract The 1α, 25, 26‐trihydroxy metabolite of vitamin D 3 , isolated from bovine serum, was shown to possess the (25 S )‐configuration by HPLC. comparison of the 1, 3, 26‐triacetate derivative with authentic (25 R )‐ and (25 S )‐samples. The convergent synthesis of (25 R )‐1α, 25, 26‐ and (25 S )‐1α, 25, 26‐trihydroxycholecalciferols ( 10a ) and ( 10b ) has been accomplished.