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Eine neue Synthese von DL ‐Armentomycin und verwandten 2‐Amino‐4‐polyhalobuttersäuren
Author(s) -
Heinzer Franz,
Martin Pierre
Publication year - 1981
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19810640514
Subject(s) - chemistry , amino acid , stereochemistry , yield (engineering) , biochemistry , metallurgy , materials science
A New Synthesis of DL ‐Armentomycin and Related 2‐Amino‐4‐polyhalobutyric Acids An efficient method for the synthesis of 2‐amino‐4‐halobutyric acids 2 starting from the corresponding ethyl 2,4‐polyhalobutyrates 1 is presented (s. Scheme 1 ). The method is illustrated by a high yield synthesis of the known antibiotic DL ‐armentomycin (= 2‐amino‐4,4‐dichlorobutyric acid; 2a ).
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