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Chiral 1, 4‐Benzodiazepin‐2‐one, template for enantioselective synthesis of α‐amino acids and their α‐deuterio congeners. Preliminary communication
Author(s) -
Decorte Enio,
Toso Roberto,
Sega Alessandro,
Šunjié Vitomir,
RužićToroš Živa,
KojićProdić Biserka,
BrescianiPahor Nevenka,
Nardin Giorgio,
Randaccio Lucio
Publication year - 1981
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19810640420
Subject(s) - chemistry , enantioselective synthesis , alkylation , stereochemistry , inversion (geology) , asymmetric induction , catalysis , organic chemistry , paleontology , structural basin , biology
Absolute conformation of 7‐chloro‐5‐phenyl‐1‐[( S )‐α‐phenylethyl]‐1, 3‐dihydro‐2 H ‐1, 4‐benzodiazepin‐2‐one ( 1c ) in crystal, and its inversion rate in solution were determined, enabling prognosis of direction of asymmetric induction during C(3)‐alkylation.