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Synthesis of Photoaffinity Labelling Analogues of the Peptide Hormone Bradykinin
Author(s) -
Laczko Endre,
Escher Emanuel
Publication year - 1981
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19810640302
Subject(s) - chemistry , labelling , bradykinin , peptide , residue (chemistry) , photoaffinity labeling , affinity label , stereochemistry , peptide synthesis , receptor , peptide hormone , biochemistry , combinatorial chemistry
Fourteen peptides, analogues of bradykinin and (des‐Arg 9 )bradykinin, have been synthesized by the solid‐phase method or have been obtained through chemical modification. In all these peptides an aromatic residue has been substituted by (4′‐NO 2 )Phe, (4′‐NH 2 )Phe, (4′‐N 3 )Phe or (4′‐NH 2 ‐3′, 5′‐I 2 )Phe. These peptides will be used as photoaffinity labelling or affinity labelling probes for peptide hormone receptors.