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Reactions of Disulfides Derived from Penicillin Sulfoxides with Tertiary Phosphines in Presence of Carboxylic Acids
Author(s) -
Prasad Kapa,
Hamberger Helmut,
Stüutz Peter,
Schulz Gerhard
Publication year - 1981
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19810640128
Subject(s) - chemistry , penicillin , disulfide bond , carboxylic acid , flue gas desulfurization , combinatorial chemistry , organic chemistry , antibiotics , medicinal chemistry , biochemistry
Abstract A novel method for the preparation of thioesters starting from Iso‐ Fujisawa disulfides is reported. The presence of an acylamino group cis to the disulfide function on the β‐lactam nucleus seems to be an essential requirement for this reaction. In the absence of such a cis ‐acylamino group, desulfurization, is the preferred course.