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Lipophilic Di‐ and Triamides as Ionophores for Alkaline Earth Metal Cations
Author(s) -
Erne Daniel,
Stojanac Nada,
Ammann Daniel,
Hofstetter Peter,
Pretsch Ernö,
Simon Wilhelm
Publication year - 1980
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19800630816
Subject(s) - chemistry , ionophore , selectivity , alkaline earth metal , membrane , inorganic chemistry , metal , ion , metal ions in aqueous solution , medicinal chemistry , stereochemistry , organic chemistry , biochemistry , catalysis
Different electrically neutral lipophilic di‐ and triamides were prepared and their ion selectivity in membranes studied. In membranes the ionophore N , N′ ‐diheptyl‐ N , N′ ‐dimethyl‐succinamide prefers Ca 2+ over Mg 2+ by a factor of 20 but rejects Na + and K + in respect to Mg 2+ by a factor of 100 and 10, respectively. This selectivity suffices to perform useful intracellular Mg 2+ activity studies.