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Synthese und Eigenschaften von 6‐Desoxy‐6‐halogen‐Derivaten der L ‐Ascorbinsäure
Author(s) -
Kiss Joseph,
Berg Klaus Peter,
Dirscherl Adolf,
Oberhänsli Willi E.,
Arnold Wolf
Publication year - 1980
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19800630642
Subject(s) - chemistry , ascorbic acid , halogen , derivative (finance) , stereochemistry , medicinal chemistry , organic chemistry , alkyl , food science , financial economics , economics
Synthesis and Properties of 6‐Deoxy‐6‐halogeno‐Derivatives of L ‐Ascorbic Acid 6‐Deoxy‐6‐chloro‐, ‐6‐bromo‐, ‐6‐iodo‐ and ‐6‐fluoro derivatives of L ‐ascorbic acid have been synthesized and characterized. The physiological properties of the chloro derivative have been investigated. It shows a high antiscurvy activity. The chloro‐ and bromo‐derivatives have been reduced to the corresponding deoxy compound, which is an interesting chiral intermediate for the preparation of rare ω‐deoxy sugars.