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Differential Hydrogen Exchange During Biosynthesis of Cytochalasins B and D
Author(s) -
Wyss Ronald,
Tamm Christoph,
Vederas John C.
Publication year - 1980
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19800630622
Subject(s) - chemistry , cytochalasin , deuterium , biosynthesis , stereochemistry , organic chemistry , biochemistry , enzyme , physics , quantum mechanics , cytoskeleton , cell
Sodium [2‐ 13 C,2‐ 2 H 3 ]acetate was incorporated into cytochalasin B( 1 ) by Phoma exigua and into cytochalasin D ( 2 ) by Zygosporium masonii . The 13 C‐NMR. and 2 H‐NMR. of the metabolites showed that most of the deuterium was lost except at carbon atoms which are in polyketide chain‐initiating units.