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Formation of N ‐Hydroxy‐amines of Spin Labeled Nucleosides for 1 H‐NMR. Analysis
Author(s) -
Ozinskas Alvydas J.,
Bobst Albert M.
Publication year - 1980
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19800630609
Subject(s) - chemistry , sodium dithionite , amine gas treating , amine oxide , radical , oxide , acetone , sodium , medicinal chemistry , sodium hydroxide , inorganic chemistry , organic chemistry , alkyl
Amine‐oxide radical 1a was efficiently converted to the corresponding N ‐hydroxy‐amine 2a with sodium dithionite in acetone/water. This reaction was used to develop a procedure for monitoring the NMR. spectra of sodium dithionite reduced amine‐oxide radicals and of novel reduced amine‐oxide‐labeled nucleosides.