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The Penems, a New Class of β‐Lactam Antibiotics. 6. Synthesis of 2‐alkylthiopenem carboxylic acids
Author(s) -
Lang Marc,
Prasad Kapa,
Gosteli Jaques,
Woodward Robert B.
Publication year - 1980
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19800630436
Subject(s) - chemistry , lactam , phosphorane , intramolecular force , wittig reaction , stereochemistry , antibiotics , bicyclic molecule , combinatorial chemistry , biochemistry
A synthesis of 2‐alkylthiopenems by an intramolecular Wittig ‐type reaction between a phosphorane and a trithiocarbonate ester is described.