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Nickel‐catalyzed Asymmetric Alkylation of Some Chiral and Achiral Allylic Alcohols. Preliminary communication
Author(s) -
Consiglio Giambattista,
Morandini Franco,
Piccolo Oreste
Publication year - 1980
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19800630427
Subject(s) - chemistry , alkylation , reagent , allylic rearrangement , tsuji–trost reaction , enantiomer , catalysis , nickel , substrate (aquarium) , enantioselective synthesis , chloride , medicinal chemistry , organic chemistry , oceanography , geology
[(−) ( R )‐1,2‐bis (Diphenylphosphino)‐1‐phenylethane]nickel (II) chloride was found to catalyze the asymmetric alkylation of some chiral and achiral allylic alcohols with Grignard reagents, leading to the formation of optically active olefins. Enantiomer discrimination of the substrate takes place in the alkylation of chiral allylic alcohols.