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Erhöhung der Nachweisempfindlichkeit von Cyclosporin A durch Derivatisierung mit 2‐Naphthylselenylchlorid
Author(s) -
Gfeller JeanClaude,
Beck Albert K.,
Seebach Dieter
Publication year - 1980
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19800630323
Subject(s) - chemistry , derivatization , tetrahydrofuran , detection limit , derivative (finance) , chromatography , high performance liquid chromatography , stereochemistry , organic chemistry , solvent , financial economics , economics
Enhancement of Detection Sensitivity of Cyclosporin A by Derivatization with 2‐Napthylselenylchloride The UV./HPLC. detection sensitivity of cyclosporine A 1 , an immunosuppressive cyclic undecapeptide containing one D‐aminoacid and seven N ‐methylated aminoacids, is enhanced by a factor of 3‐4 (limit of detection 5 ng) by conversion of the characteristic side chain of amino‐acid‐1 to the β‐naphthylseleno‐substituted tetrahydrofuran derivative 4 .
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