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Eine einfache Methode zur Herstellung von Benzoxazolen
Author(s) -
Seha Zdenek,
Weis Claus D.
Publication year - 1980
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19800630212
Subject(s) - chemistry , yield (engineering) , chloride , organic chemistry , medicinal chemistry , metallurgy , materials science
A Facile Method for the Synthesis of Benzoxazoles The preparation of benzoxazoles by a facile one‐pot reaction is reported. The reaction of carboxylic acids with 2‐chloro‐ N ‐methyl‐Δ 1 ‐pyrrolinium chloride in an excess of N ‐methyl‐2‐pyrrolidone afforded carboxylic acid chlorides which were converted subsequently to their 2‐hydroxyanilides by addition of 2‐aminophenols. Cyclization of the 2‐hydroxy‐anilides at elevated temperatures furnished the benzoxazoles in high yield and purity.