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Total Synthesis of Indole and Dihydroindole Alkaloids. XVIII . Isomers and analogues of vinblastine
Author(s) -
Kutney James P.,
Honda Toshio,
Kazmaier Peter M.,
Lewis Norman J.,
Worth Brian R.
Publication year - 1980
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19800630206
Subject(s) - chemistry , indole test , vinblastine , total synthesis , stereochemistry , medicine , surgery , chemotherapy
The synthesis and conformational analysis of (3′ R )‐3‐hydroxyleurosidine ( 5 ), (3′ S )‐3‐hydroxyleurosidine ( 10 ), (3′ S )‐3‐acetoxy‐4′‐deoxyleurosidine ( 15 ), (3′ R )‐3‐acetoxy‐4′‐deoxyleurosidine ( 23 ), (3′ R )‐3‐acetoxy‐4′‐deoxyvinblastine ( 16 ), (3′ S )‐3‐acetoxy‐4′‐deoxyleurosidine ( 28 ) is discussed.
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