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Stereochemistry‐Activity Relationships in Olfaction. Odorants containing a proton donor/proton acceptor unit
Author(s) -
Ohloff Günther,
Giersch Wolfgang
Publication year - 1980
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19800630109
Subject(s) - chemistry , odor , stereospecificity , stereochemistry , acceptor , olfaction , ionone , proton , organic chemistry , catalysis , psychology , neuroscience , physics , quantum mechanics , condensed matter physics
A novel class of odorants is described where the odor is associated with the interaction of two functional groups, one being an H‐donor (AH function), and the other an H ‐acceptor ( B function). Generally, odor occurs only if the distance between the two structural elements (AH/B system) is less than 3 Å. Bifunctional derivatives of the p ‐menthane and iridane series served as models for deriving this rule. The stereospecificity of odor perception was an important prerequisite for its establishment.