Premium
Recherche d'analogues de nucléosides à activité antivirale
Author(s) -
Tronchet Jean M. J.,
Valero Miguel J.
Publication year - 1979
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19790620828
Subject(s) - chemistry , herpes virus , virus , impossibility , nucleoside , virology , stereochemistry , medicinal chemistry , political science , law , biology
Search for Antiviral Nucleosides Analogues In contrast to the reported impossibility of obtaining the expected products when 1‐(2,3‐ O ‐isopropylidene‐1,5‐dialdoribofurannos‐1‐yl)uracile ( 2 ) was treated with stabilized ylides, we prepared in good to excellent yields the modified nucleosides 4–9 by reaction of 2 respectively with acetylmethylidene‐, benzoylmethylidene‐, ethoxymethylidene‐, methoxymethylidene‐, succinimidylidene‐ or N ‐phenylsuccinimidylidene‐triphenylphosphorane. Compounds 4–10 were tested against the herpes virus type 1 (HF) and influenza virus A 2 /Scotland. The modified nucleoside 9 showed a limited but significative activity against the herpes virus.