Recherche d'analogues de nucléosides à activité antivirale | Zendy

Tronchet Jean M. J. | Zendy; Valero Miguel J. | Zendy

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Recherche d'analogues de nucléosides à activité antivirale

Author(s) -

Tronchet Jean M. J.,

Valero Miguel J.

Publication year - 1979

Publication title -

helvetica chimica acta

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.74

H-Index - 82

eISSN - 1522-2675

pISSN - 0018-019X

DOI - 10.1002/hlca.19790620828

Subject(s) - chemistry , herpes virus , virus , impossibility , nucleoside , virology , stereochemistry , medicinal chemistry , political science , law , biology

Search for Antiviral Nucleosides Analogues In contrast to the reported impossibility of obtaining the expected products when 1‐(2,3‐ O ‐isopropylidene‐1,5‐dialdoribofurannos‐1‐yl)uracile ( 2 ) was treated with stabilized ylides, we prepared in good to excellent yields the modified nucleosides 4–9 by reaction of 2 respectively with acetylmethylidene‐, benzoylmethylidene‐, ethoxymethylidene‐, methoxymethylidene‐, succinimidylidene‐ or N ‐phenylsuccinimidylidene‐triphenylphosphorane. Compounds 4–10 were tested against the herpes virus type 1 (HF) and influenza virus A 2 /Scotland. The modified nucleoside 9 showed a limited but significative activity against the herpes virus.

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