The Structure of the Antibiotic Hedamycin. V. Crystal structure and absolute configuration | Zendy

Zehnder Margareta | Zendy; Séquin Urs | Zendy; Nadig Heinz | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

The Structure of the Antibiotic Hedamycin. V. Crystal structure and absolute configuration

Author(s) -

Zehnder Margareta,

Séquin Urs,

Nadig Heinz

Publication year - 1979

Publication title -

helvetica chimica acta

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.74

H-Index - 82

eISSN - 1522-2675

pISSN - 0018-019X

DOI - 10.1002/hlca.19790620803

Subject(s) - orthorhombic crystal system , chemistry , absolute configuration , crystal structure , crystallography , ring (chemistry) , substituent , optical rotation , stereochemistry , organic chemistry

The crystal structure of the antibiotic hedamycin ( 1 ) has been solved by direct method and refined by least squares techniques to R = 0.091 for 2289 of 2643 independent reflexions. Crystals of C 41 H 50 N 2 O 11 are orthorhombic, space group P2 1 2 1 2 1 with lattice parameters a = 24.239 (12), b = 21.440 (10), c = 7.369 (4) Å, Z = 4. The structural features of hedamycin derived earlier by chemical and spectroscopical means are confirmed. Optical rotation and circular dichroism indicate that hedamycin ( 1 ) has the absolute configuration of the related antibiotic kidamycin ( 3 ). The conformation of ring F is a chair form with the aryl substituent almost axial. The bioxirane part of the antibiotic is in a synclinal conformation.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research