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Influence of Amino Acids, Ammonium and Potassium Cations on the Self‐Assembly of 5′‐GMP
Author(s) -
Detellier Christian,
Laszlo Pierre
Publication year - 1979
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19790620521
Subject(s) - chemistry , potassium , ammonium , ion , guanosine , inorganic chemistry , salt (chemistry) , sodium , aqueous solution , guanine , supramolecular chemistry , alanine , amino acid , medicinal chemistry , crystallography , organic chemistry , crystal structure , biochemistry , nucleotide , gene
The self‐ordered supramolecular structures formed by 5′‐guanosine monophosphate (disodium salt) in aqueous solution at pH 7.8 show pronounced interaction with ammonium ions. Rather than competing with potassium ions for the central cavity in hydrogen‐bonded guanine tetramers, ammonium ions bring about ‐ in synergism with potassium ions ‐ further aggregation. Glycine appears to destroy the aggregates, by competing with potassium ions for the core positions within the tetramers. Conversely, alanine does not interact significantly with the system. These conclusions follow from analysis, at various concentrations, of the microdynamics and of the mole fractions of sodium ions bound to self‐assembled 5′‐GMP −− , obtained from relaxation rate measurements for the 23 Na nucleus, as the 5′‐GMP −− counter‐ion.