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A Novel Synthesis of Aporphines via 3‐Phenylphenethylamines
Author(s) -
Gerecke Max,
Brossi Arnold
Publication year - 1979
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19790620520
Subject(s) - chemistry , aporphine , alkoxy group , stereochemistry , combinatorial chemistry , medicinal chemistry , organic chemistry , alkaloid , alkyl
rac ‐1,2,10‐Trimethoxy‐aporphine ( 14 ) and rac ‐2‐ethoxy‐10,11‐dimethoxyaporphine ( 27 ) have been synthesized from the 3‐phenylphenethylamines 9 and 22 by a new route. The 8‐phenyl‐3,4‐dihydroisoquinolines 11 and 24 , the oxo‐aporphines 12 and 25 and the rac ‐nor‐aporphines 13 and 26 were obtained as intermediates.