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Anil‐Synthese. 20. Mitteilung . Über die Herstellung von Stilbenyl‐Derivaten des 1,2,4,‐Oxadiazols
Author(s) -
Berger Hanny,
Siegrist Adolf Emil
Publication year - 1979
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19790620506
Subject(s) - chemistry , potassium hydroxide , yield (engineering) , reactivity (psychology) , dimethylformamide , medicinal chemistry , potassium , ring (chemistry) , organic chemistry , medicine , materials science , alternative medicine , pathology , solvent , metallurgy
Preparation of Stilbenyl Derivatives of 1,2,4‐Oxadiazoles Schiffs bases derived from 3‐ and 5‐( p ‐formylphenyl)‐phenyl‐1,2,4‐oxadiazoles and chloroanilines are reacted with various p ‐tolyl substituted aromatic heterocycles in the presence of dimethylformamide and potassium hydroxide to yield the corresponding heterocyclic substituted stilbenes (‘Anil synthesis’). The reactivity of 5‐[4‐(chlorophenylimino‐methyl)phenyl]‐3‐phenyl‐1,2,4‐oxadiazoles is very low and side reactions will predominate.