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Synthese und Konfiguration einiger Spiro [indan‐2,2′‐pyrrolidin]‐ und Spiro [pyrrolidin‐2,2′‐tetralin]‐Derivate ,
Author(s) -
Stoll André P.,
Petcher Trevor James,
Weber Hans Peter
Publication year - 1979
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19790620433
Subject(s) - chemistry , pyrrolidine , tetralin , catalytic hydrogenation , stereochemistry , catalysis , medicinal chemistry , organic chemistry
Synthesis and configuration of some spiro [indan‐2,2′‐pyrrolidine] and spiro [pyrrolidine‐2,2′‐tetraline] derivatives Catalytic hydrogenation of the nitrosoindan and nitrosotetralin derivatives 8 yielded trans ‐1‐hydroxy‐spiro [indan‐2,2′‐pyrrolidin]‐5′‐one ( 9 ) and trans ‐1′‐hydroxy‐spiro [pyrrolidine‐2,2′‐tetralin]‐5‐one ( 10 ) respectively, whilst the corresponding cis compounds 12 and 15 were prepared via the chlorides 11 and 14 . The configurations of 10 and 13 were determined by X‐Ray analysis.