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Synthese eines 33gliedrigen Polyaminolactams durch Anwendung der «zip»‐Reaktion. 6. Mitteilung über Umamidierungsreaktionen
Author(s) -
Kramer† Urs,
Schmid† Hans,
Guggisberg Armin,
Hesse Manfred
Publication year - 1979
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19790620317
Subject(s) - chemistry , derivative (finance) , reagent , yield (engineering) , lactam , potassium , medicinal chemistry , stereochemistry , organic chemistry , materials science , financial economics , economics , metallurgy
Synthesis of a 33‐membered Polyaminolactam by Use of the Zip‐reaction The pentaamino lactam derivative 11 was synthesized from the 13‐membered tosylaminolactam 2 . The prolongation of the side chain was achieved using the phthalimido derivative 3 . After removal of the protecting groups the resulting base 11 was treated with KAPA reagent (1,3‐propanediamine/potassium‐3‐aminopropyl‐amid). By zip‐reaction the 33‐membered 13, 17, 21, 25, 29‐pentaaza‐32‐dotriacontanelactam ( 1 ) was formed in 85% yield.