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Anil‐Synthese. 19. Mitteilung . Über die Herstellung von Stilbenyl‐Derivaten des Isoxazols
Author(s) -
Berger Hanny,
Siegrist Adolf Emil
Publication year - 1979
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19790620315
Subject(s) - chemistry , potassium hydroxide , yield (engineering) , dimethylformamide , medicinal chemistry , potassium , organic chemistry , solvent , materials science , metallurgy
Preparation of Stilbenyl Derivatives of Isoxazoles Schiff 's bases derived from 3‐ and 5‐( p ‐formylphenyl)‐phenylisoxazoles and o ‐ or p ‐chloroaniline are reacted with various p ‐tolyl substituted aromatic heterocycles in the presence of dimethylformamide and potassium hydroxide or potassium t ‐but‐oxide to yield the corresponding heterocyclic substituted stilbenes (‘Anil synthesis’). 5‐[4‐(Chlorphenylimino‐methyl)phenyl]‐phenylisoxazoles react less readily than the corresponding 3‐isomers.