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13 C‐NMR. Analysis of Dihydrogranaticin Methyl Ester. A case of mixed biogenesis
Author(s) -
Ar Alberto,
Camarda Lorenzo,
Cardillo Rosanna,
Fronza Giovanni,
Merlini Lucio,
Mondelli Rosanna,
Nasini Gianluca,
Pyrek Jan St.
Publication year - 1979
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19790620105
Subject(s) - chemistry , moiety , biogenesis , polyketide , streptomyces , stereochemistry , carbon 13 nmr , organic chemistry , biochemistry , gene , biosynthesis , bacteria , enzyme , genetics , biology
The 13 C‐NMR. spectrum of dihydrogranaticin methyl ester has been completely analyzed. Feeding experiments of CH 3 13 COONa to a culture of Streptomyces olivaceus have shown that only a sixteen carbon moiety of the antibiotic granaticin is of polyketide origin, thus confirming the hypothesis of a mixed biogenesis for this natural substance.