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S‐Alkylation en série hétérocyclique par catalyse par transfert de phase: thioalkyl‐2‐thiazoles, thioalkyl‐2‐Δ‐4‐thiazolines et thioalkyl‐2‐benzothiazoles
Author(s) -
Dou Henri J. M.,
Hassanaly Parina,
Kister Jacky,
Vernin Gaston,
Metzger Jacques
Publication year - 1978
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19780610842
Subject(s) - chemistry , alkylation , thiazolidine , catalysis , medicinal chemistry , reactivity (psychology) , nucleophile , thiazoline , stereochemistry , organic chemistry , medicine , alternative medicine , pathology
S‐Alkylation in heterocyclic serie by phase transfer catalysis: 2‐alkylthiothiazoles, 2‐alkylthio‐Δ‐4‐thiazolines and 2‐alkylthiobenzothiazoles Some Δ‐4‐thiazoline‐, thiazolidine‐, and benzothiazoline‐2‐thiones have been S‐alkylated by phase transfer catalysis; yields averaged 80 to 90%. With halogenated heterocyclic compounds of poor reactivity, the main reaction consisted in a dequaternization of the catalyst by the thiones acting as nucleophiles.