Efficient Conversion of Esters to α‐Trimethylsilylketones. Preliminary communication | Zendy

Demuth Martin | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Efficient Conversion of Esters to α‐Trimethylsilylketones. Preliminary communication

Author(s) -

Demuth Martin

Publication year - 1978

Publication title -

helvetica chimica acta

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.74

H-Index - 82

eISSN - 1522-2675

pISSN - 0018-019X

DOI - 10.1002/hlca.19780610840

Subject(s) - chemistry , trimethylsilyl , primary (astronomy) , ketone , sequence (biology) , organic chemistry , reaction conditions , combinatorial chemistry , catalysis , biochemistry , physics , astronomy

Secondary and tertiary carboxylic methyl or ethyl esters ( 2a‐c ) were converted with trimethylslylmethyllithium ( 3a‐c ) in high yields. Under identical reaction conditions the primary esters 2d,e gave 3d, e in lower yields. Since the trimethylsilyl (TMS) group α to a ketone is known to undergo facile elimination under a variety of reaction conditions, the method also constitutes a highly versatile ester to methylketone sequence.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research