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«Push‐Pull»‐Acetylene als Hilfsmittel zur Synthese von Amiden
Author(s) -
Neuenschwander Markus,
Lienhard Ulrich,
Fahrni HansPeter,
Hurni Beat
Publication year - 1978
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19780610715
Subject(s) - chemistry , acetylene , amide , selectivity , yield (engineering) , amine gas treating , reagent , enol , organic chemistry , combinatorial chemistry , catalysis , metallurgy , materials science
Amide Synthesis by Means of ‘Push‐Pull’‐Acetylenes ‘Push‐Pull’‐acetylenes react easily with carbon acids, Addition of amines to the crude reaction mixture gives amides in an excellent yield by a simple one‐pot procedure. Because of the high selectivity of the acetylenes 1 towards carboxylic functions and of the high selectivity of the enol esters 4 towards amine functions, ‘push‐pull’‐acetylenes could be excellent reagents for peptide synthesis.