Premium
Über Pterinchemie 67. Mitteilung Zum Verlauf der katalytischen Reduktion von 6, 7‐Diphenylpterin
Author(s) -
Antoulas Symeon,
Bieri Jost H.,
Viscontini Max
Publication year - 1978
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19780610628
Subject(s) - chemistry , pyrazine , catalytic hydrogenation , ring (chemistry) , catalysis , double bond , medicinal chemistry , stereochemistry , reduction (mathematics) , organic chemistry , mathematics , geometry
On the pathway of the catalytic reduction of 6,7‐diphenylpterin The pathway of the hydrogen addition to the pyrazine ring of 6, 7‐diphenylpterin ( 1a ) during acid‐catalyzed reduction was elucidated. Initial hydrogenation of the 5, 6‐double bond produces 6, 7‐diphenyl‐5, 6‐dihydropterin ( 2a ); this then undergoes a [1, 2]‐H‐rearrangement, which yields the thermodynamically more stable 6, 7‐diphenyl‐7, 8‐dihydropterin ( 3a ). Subsequent reduction of 3a gives 4 .