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Reaction of aminoalcohols with butadiene catalyzed by palladium complexes. Preliminary communication
Author(s) -
Umpleby J. David
Publication year - 1978
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19780610627
Subject(s) - chemistry , palladium , triphenylphosphine , triethylamine , catalysis , 1,3 butadiene , molar ratio , medicinal chemistry , organic chemistry
The aminoalcohols 1 , react with 2 equivalents of butadiene in the presence of catalytic quantities of bis (acetylacetonato)palladium/triphenylphosphine to give exclusively the corresponding N ‐octadienyl amninoalcohols. In the presence of excess butadiene, subsequent O ‐octadienylation occurs only for N ‐octadienylimino‐diethanol 2g , affording the monoether 4g . O ‐octadienylation of 2a‐f and 4g can be effected by the addition of molar quantities of triethylamine to the reaction mixture.