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15 N‐NMR. Spectra of pterins and folic acid derivatives
Author(s) -
Schwotzer Willi,
Bieri Jost H.,
Viscontini Max,
von Philipsborn Wolfgang
Publication year - 1978
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19780610618
Subject(s) - chemistry , protonation , chemical shift , folic acid , nitrogen , spectral line , nmr spectra database , medicinal chemistry , stereochemistry , organic chemistry , ion , physics , astronomy , medicine
15 N‐Chemical shifts of a series of 5, 6, 7, 8‐tetrahydropterins, 7, 8‐dihydropterins and pterins have been measured in acidic solution by means of a probe for 20 mm sample tubes. Included are the relevant data of folic acid (11) , 5, 6, 7, 8‐tetrahydrofolic acid (5) and N (5, 10)‐metheno‐5, 6, 7, 8‐tetrahydrofolic acid (6) . The different oxidation states are clearly relected in the chemical shifts of N (5) and N (8). Assignment of the nitrogen resonances was achieved by protonation effects (discrimination between N (1) and N (3)) and with the aid of alkyl substitution at C (6) and C(7), to distinguish between N (5) and N (8).