Premium
Biosynthesis of Mikrolin
Author(s) -
Chexal Kuldip K.,
Tamm Christoph
Publication year - 1978
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19780610609
Subject(s) - chemistry , acetic acid , aqueous solution , tautomer , biosynthesis , sodium acetate , sodium , stereochemistry , medicinal chemistry , organic chemistry , enzyme
Mikrolin (8) and dechloromikrolin (9) have been shown to exist as tautomeric mixtures in solution. The structures of mono‐O‐trifluoroacetyl Mikrolin (10) and di‐O‐acetyl Mikrolin (11) have been elucidated. The products 15 to 23 from reduction of the metabolites 8 9 with Pd/C and Zn in aqueous acetic acid have been identified. The 13 C‐NMR. spectra of Mikrolin (8) and dechloromikrolin (9) and their derivatives have been completely assigned Based on the results of incorporation experiments with sodium [1‐ 13 C]‐, [2‐ 13 C]‐ and [1, 2‐ 13 C]‐acetate, a biosynthetic pathway is proposed for Mikrolin (8) .