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Structures of Addition Products of Acetylenedicarboxylic Acid Esters with Various Dinucleophiles. An application of C, H‐spin‐coupling constants
Author(s) -
Vögeli Ulrich,
von Philipsborn Wolfgang,
Nagarajan Kuppuswamy,
Nair Mohan D.
Publication year - 1978
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19780610207
Subject(s) - chemistry , coupling constant , coupling (piping) , spin (aerodynamics) , computational chemistry , stereochemistry , combinatorial chemistry , thermodynamics , quantum mechanics , mechanical engineering , physics , engineering
Heterocyclic compounds obtained by addition of acetylenedicarboxylic acid esters to thioureas, cyclic amidines and o ‐difunctionalized aromatic systems have been studied by 13 C‐NMR. In particular, C, H‐spin‐coupling constants over two and three bonds were used to differentiate between the various constitutional isomers and to establish the configuration of trisubstituted exocyclic C, C‐double bonds. The configurational significance and diagnostic value of vicinal cis and trans C,H‐spin coupling is again demonstrated in the present series.