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ε‐Aminocaproylcholine: Chemical Synthesis, Biological Properties, and Interactions with Receptor Molecules
Author(s) -
Frank Jörg,
Kriwaczek Verena Marly,
Marchand Claudine,
Schwyzer Robert
Publication year - 1977
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19770600808
Subject(s) - chemistry , carbachol , acetylcholine , agonist , acetylcholine receptor , cholinergic , sepharose , potency , receptor , nicotinic agonist , hydrolysis , biological activity , biochemistry , stereochemistry , enzyme , pharmacology , in vitro , medicine
ε‐Aminocaproylcholine, [ 14 CH 3 ‐]ε‐aminocaproylcholine, and their Sepharose‐2B derivatives ( 6 ) were synthesized. ε‐Aminocaproylcholine is a full cholinergic agonist (nicotinic) with a potency intermediate between that of acetylcholine and of carbachol. ε‐Aminocaproylcholine is not hydrolysed by acetylcholine esterase, but is an inhibitor. Its Sepharose‐2B derivatives are shown to be effective affinity‐chromatographic agents for the isolation of acetylcholine‐binding proteins (receptors).