Premium
Reactions with Carbo(heterylhydrazonoyl) Halides. I. Chemistry of Carbo(3‐phenylpyrazol‐5‐yl‐hydrazonoyl) Chlorides
Author(s) -
Elmoghayar Mohamed Rifaat Hamza,
Elnagdi Mohamed Hilmy,
Ibrahim Mohamed Kamal Ahmed,
Sallam Mohamed Mohamed Mohamed
Publication year - 1977
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19770600709
Subject(s) - chemistry , yield (engineering) , hydrazine (antidepressant) , methylene , carbon disulfide , hydrate , medicinal chemistry , halide , pyrazole , isothiocyanate , phenyl isothiocyanate , malononitrile , organic chemistry , materials science , chromatography , metallurgy , catalysis
The Carbo(3‐phenylpyrazol‐5‐yl‐hydrazonoyl) halides 1a , b react with active methylene compounds to yield the 1‐(3‐phenylpyrazol‐5‐yl)‐pyrazole derivatives 2a – k ( Scheme 1 ). The acyclic intermediates 3a , b could be isolated from reaction of 1a , b with acetylacetone, thus establishing the substitution mechanism for these reactions. Compounds 1a , b reacted with carbon disulfide, phenyl isothiocyanate, methyl cyanide, and with p ‐chlorobenzaldehyde to yield the corresponding heterocyclic derivatives 5 – 8 , respectively ( Scheme 2 ). The behaviour of compounds 2 with hydrazine hydrate is reported.