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Rearrangement of Cephem Bromohydrins to Thiazepine Derivatives
Author(s) -
Petrzilka Theodor,
Prasad Kapa K.,
Schmid Gerard
Publication year - 1977
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19770600628
Subject(s) - cephem , chemistry , combinatorial chemistry , organic chemistry , carboxylic acid
Abstract A new rearrangement of cephem bromohydrins 2 – 5 to thiazepine derivatives 7 – 8 is described. The structure of the rearrangement product is established by an independent synthesis. The probable mechanism of the above rearrangement is discussed.