Un nouvel analogue synthétique de l'adénosine: La désoxy‐3′‐ C ‐dibromométhylidène‐3′‐adénosine

A novel synthetic analog of adenosine: the 3′‐deoxy‐3′‐ C ‐dibromomenthylidene‐adenosine The title compound ( 7 ) has been prepared by a sequence of classical synthetic steps from 3‐deoxy‐3‐ C ‐dibromomethylidene‐1,2: 5,6‐di‐ O ‐isopropylidene‐α‐ D ‐ ribo ‐hexofuranose ( 1 ). The β‐configuration of the nucleoside was established by formation of a cyclonucleoside. 7 is very slowly deaminated by adenosine deaminase. In contrast with its dichloro analog, it does not inhibit the growth of Escherichia coli .