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Zur Reaktion von monosubstituierten Epoxypropanen mit Benzylamin. 1. Mitteilung über Ringöffnungsreaktionen kleiner Ringe
Author(s) -
Sulser Ueli,
Widmer Jürg,
Goeth Heinz
Publication year - 1977
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19770600523
Subject(s) - chemistry , benzylamine , epoxide , ring (chemistry) , activation energy , reaction rate constant , medicinal chemistry , stereochemistry , organic chemistry , kinetics , catalysis , physics , quantum mechanics
Reaction of monosubstituted epoxypropanes with benzylamine The reaction of the epoxides of the general formulawith benzylamine at 40, 50 and 60°C has been examined. The determination of rate constants by variation of X has shown, that in the case of X = S or N no anchimeric acceleration occurred. These results have been approved by product analysis and by synthesis of the possible reaction products. Transition states of the epoxide/benzyl‐amine reaction are discussed by means of the experimentally determined activation energy and activation entropy.