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Verrucarin K, the First Natural Trichothecene Derivative Lacking the 12,13‐Epoxy Group. Verrucarins and Roridins. 34th Communication [1]
Author(s) -
Breitenstein Werner,
Tamm Christoph
Publication year - 1977
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19770600509
Subject(s) - chemistry , stereochemistry , metabolite , derivative (finance) , strain (injury) , trichothecene , hydrolysis , natural product , organic chemistry , biochemistry , mycotoxin , food science , medicine , financial economics , economics
A new metabolite, verrucarin K (C 27 H 34 O 8 ) has been isolated from a strain of Myrothecium verrucaria (A LBERTINI et S CHWEINITZ ) D ITMAR ex F RIES . On the basis of spectral and chemical evidence structure 1 was assigned to the new compound. Base‐catalysed hydrolysis yielded verrucarinolactone ( 5 ), E , Z ‐muconic acid ( 6 ) and trichotheca‐9, 12‐diene‐4,15‐diol ( 3 ). The implications of 1 in the trichothecane biosynthesis are discussed.