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Building Blocks for the Synthesis of Maytansinoids. Preliminary Communication
Author(s) -
Götschi Erwin,
Schneider Fernand,
Wagner Hans,
Bernauer Karl
Publication year - 1977
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19770600433
Subject(s) - chemistry , moiety , aldehyde , ketone , dithiane , combinatorial chemistry , stereochemistry , organic chemistry , catalysis
The dienal 14 and the ketone 19 , both potential building blocks of maytansinoids, were synthesized starting from ethyl vanillate ( 2 ) via the aldehyde 9 . It could be shown in a preliminary experiment that the dienal 14 can be coupled with 2‐lithio‐1,3‐dithiane to afford compound 16 which exhibits the correctly substituted aromatic part of maytansine as well as its C(9) to C(15) moiety.