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The Structure of the Antibiotic Hedamycin. I. Chemical, Physical and Spectral Properties
Author(s) -
Séquin Urs,
Bedford Colin T.,
Chung Sung K.,
Scott A. Ian
Publication year - 1977
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19770600320
Subject(s) - chemistry , tetrahydropyran , molecule , ketone , chemical structure , stereochemistry , epoxy , chemical shift , organic chemistry , ring (chemistry)
Interpretation of the chemical and spectral (IR., UV., 1 H‐ and 13 C‐NMR.) properties of the antitumor antibiotic hedamycin (C 41 H 50 N 2 O 11 ) suggests that the molecule contains a methyl substituted 1‐hydroxyanthraquinone nucleus, an α, β‐unsaturated ketone, two sugar‐like tetrahydropyran rings ( 4 and 8 ) and an aliphatic chain 2 , presumably with an epoxy group (see the Scheme ).