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Sterische Einflüsse auf die Dissoziationskonstanten von acyclischen, mono‐ und bicyclischen Carbonsäuren
Author(s) -
Grob Cyril A.,
Schweizer Thomas,
Wenk Paul,
Wild Rolf S.
Publication year - 1977
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19770600220
Subject(s) - chemistry , steric effects , bicyclic molecule , dissociation constant , medicinal chemistry , stereochemistry , solvation , solvent , organic chemistry , biochemistry , receptor
Steric effects on the dissociation constants of acyclic, mono‐ and bicyclic carboxylic acids Apparent p K a *values for the series of acyclic, mono‐ and bicyclic acids 1–14 have been measured in 50% ( W / W ) ethanol (see the Table). The dissociation constants of these acids decrease as the access of the solvent to the carboxylate group is hindered by the rest of the molecule. These results emphasize the importance of solvation in determining acid strength. New or improved syntheses of several of the acids investigated are reported.