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Über Pterinchemie. 58. Mitteilung [1]. Sterische Eigenschaften von acylierten 5,6,7,8‐Tetrahydropterinen . Rotameren von 5‐Trifluoracetyl‐tetrahydropterin‐Derivaten
Author(s) -
Weber Rudolf,
Viscontini Max
Publication year - 1977
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19770600117
Subject(s) - chemistry , trifluoroacetic acid , medicinal chemistry , trifluoroacetic anhydride , nitrogen , organic chemistry , stereochemistry
Sterochemical Properties of the Acylated 5,6,7,8‐Tetrahydropterines. Rotameres of the 5‐Trifluoroacetyl‐tetrahydropterine Derivatives 6‐Methyl‐ and 6,7‐dimethyl‐5,6,7,8‐tetrahydropterine are acylated with the anhydrides of acetic acid and trifluoroacetic acid. It is shown that the reactivity of the nitrogen otoms increases in the following order: N (3), N (8), N (2′) and N (5). Two rotameres are present in the 1 H‐NMR. spectra of the N (5)‐trifluoroacetates, but not in those of the N (5)‐acetates.