Premium
The Use of 13 C–NMR. Spectroscopy in Biosynthetic Studies. II[1]. Biosynthesis of narasin, a new polyether ionophore from fermentation of Streptomyces aureofaciens [2]
Author(s) -
Dorman Douglas E.,
Paschal Jonathan W.,
Nakatsukasa Walter M.,
Huckstep Lyell L.,
Neuss Norbert
Publication year - 1976
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19760590802
Subject(s) - chemistry , streptomyces aureofaciens , propionate , fermentation , ionophore , biosynthesis , butyrate , nuclear magnetic resonance spectroscopy , carbon 13 nmr , propionates , streptomyces , nuclear chemistry , stereochemistry , organic chemistry , bacteria , enzyme , genetics , biology , calcium
The labeling of the polyether ionophore, narasin, using 13 C‐labeled acetate, propionates, and butyrates in the course of fermentation of Streptomyces aureofacies resulted in the isolation of differently labeled compounds. A careful examination of the 13 C‐NMR. spectral data indicated derivation of narasin from five acetate, seven propionate, and three butyrate units. The evidence of indirect incorporation of 13 C led to the first documented demonstration of conversion of propionate to butyrate in the course of the synthesis of narasin by S. aureofaciens .